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Can You Mix Alcohol and Zoloft®?

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When it comes to substance abuse and drug addiction, one of the most common things is that people mix drugs and alcohol. Some drugs like benzodiazepines, SSRIs, opioids, and many more do not work well with alcohol and can lead to serious bodily harm. Alcohol and Zoloft® can be a dangerous combination. While both substances are widely used, they can have adverse effects when taken together.

In this article, we’ll look at the risks and repercussions of mixing alcohol and Zoloft®, so you can make an informed decision about your mental health and well-being the next time someone offers to try it.

What is Zoloft®?

Zoloft® is the brand name for a well-known antidepressant medication called sertraline hydrochloride. It is a selective serotonin reuptake inhibitor (SSRI) and is one of the most commonly prescribed antidepressants. Zoloft® is often prescribed to people with depression, anxiety, or obsessive-compulsive disorder (OCD).

How Do Selective Serotonin Reuptake Inhibitors Improve Mental Health?

Selective serotonin reuptake inhibitors (SSRIs) like sertraline work by altering how brain cells reabsorb the neurotransmitter serotonin, inhibiting the brain’s serotonin receptors and causing more serotonin molecules to circulate.

By increasing the amount of serotonin in the brain, Zoloft® has been shown to improve other symptoms related to mental health, such as sleep disturbance, irritability, and social phobia.

While no data has proven that low serotonin levels directly cause depression and other mental health disorders, some studies have found that increasing serotonin levels improve symptoms and make people more responsive to other types of treatment, such as cognitive behavioral therapy (CBT).

What is Sertraline (Zoloft®) Used For?

Zoloft® is a versatile medication that can be used to treat several mental health conditions, including:

  • Major depressive disorder (MDD)
  • Obsessive-compulsive disorder (OCD)
  • Post-traumatic stress disorder (PTSD)
  • Premenstrual dysphoric disorder (PMDD)
  • General anxiety disorder (GAD)
  • Panic disorder
  • Social anxiety disorder

It can also be used off-label to treat other conditions, including chronic pain, eating disorders, and sleep disturbances.

Zoloft® Side Effects

Just like any medication, Zoloft® can cause side effects. Some of the most common side effects in adults and children include:

  • Nausea
  • Diarrhea
  • Upset stomach or indigestion
  • Tremors or shaking
  • Tiredness and fatigue
  • Headache
  • Drowsiness
  • Insomnia
  • Sexual dysfunction
  • Dry mouth
  • Excessive sweating
  • Changes in mood

These side effects are usually mild and go away after a few days. However, seek medical advice immediately if any side effects persist or become severe.

Meanwhile, sexual side effects like problems with orgasm or ejaculatory delay often do not diminish over time.

Children may also experience the following:

  • Nose bleed
  • More frequent urination or urine leakage
  • Aggressiveness
  • Heavy menstrual periods
  • Slowed growth rate
  • Weight change
  • Abnormal increase in muscle movement to agitation

In rare cases, individuals may experience more severe side effects when taking Zoloft. These can include:

  • Suicide attempts
  • Acting on dangerous impulses
  • Low sodium blood levels
  • New or worse depressive symptoms
  • New or worse anxiety or panic attacks
  • Increased thoughts of suicide or dying
  • An increase in activity, such as talking more than usual
  • Severe allergic reactions (trouble breathing, swelling, rashes, or hives)
  • Seizures or convulsions
  • Abnormal bleeding
  • Manic episodes
  • Eye pain or swelling/redness around the eyes
  • Blurred or double vision

Zoloft® can also cause serotonin syndrome, which is a life-threatening condition. Symptoms of serotonin syndrome include:

  • Agitation
  • Loss of consciousness
  • Coma
  • Fast heart rate
  • Seizures
  • Hallucinations or delusions
  • Changes in blood pressure
  • Muscle tremor or stiffness
  • Dizziness
  • Sweating
  • Tremors or shaking
  • Nausea
  • Vomiting

If you experience any of these symptoms or symptoms outside of this list, please seek medical attention immediately.

Is Zoloft® Addictive?

One of the concerns people have when taking a new prescription drug such as Zoloft® is whether or not it is addictive. Zoloft® is generally safe for long-term use and has a lower addiction risk than other antidepressants. This is because, unlike other addictive substances, Zoloft® does not cause euphoria or a “high.” There are also no indications that patients crave Zoloft® like nicotine or opioids.

However, just because Zoloft® is not addictive does not mean that individuals cannot develop a dependence on the medication. This can occur when individuals become dependent on the drug to manage their mental health symptoms and struggle to stop taking it without experiencing withdrawal symptoms.

Some people also use Zoloft® even if they are no longer required to avoid withdrawal. They may also “doctor shop” or try to obtain it illegally. This type of withdrawal-relapse cycle is common among people with substance use disorder.

Please note that abusing Zoloft® or any other antidepressant drug can have dangerous consequences. This may cause serious medical and mental health issues. Discuss with your healthcare providers how to safely manage your use of Zoloft® and other prescription drugs you may be taking.

Dangers of Zoloft® Overdose

While Zoloft® can be a safe and effective treatment option for many individuals, it can be harmful when misused or abused. As such, it’s important to be aware of the signs and symptoms of an overdose.

While a Zoloft® overdose does not always necessitate a life-threatening emergency, it can lead to organ damage and may sometimes turn fatal.

Milder and more common symptoms include:

  • Nausea
  • Vomiting
  • Shaking and tremors
  • Fever
  • Agitation
  • Increased heart rate
  • Fatigue or tiredness
  • Diarrhea
  • Drowsiness

Sometimes, a Zoloft® overdose can be life-threatening and require immediate medical attention. Seek help right away if you or someone else exhibits the following symptoms:

  • Seizures
  • Delirium or hallucinations
  • Loss of consciousness
  • Muscle tightness
  • Confusion
  • Any sign of serotonin syndrome

Follow the instructions on the medication label and only take the amount of Zoloft® that your healthcare provider has prescribed. It’s also important to store Zoloft® out of reach of children and avoid taking more than one dose in a short period.

Can I Take Zoloft® With Alcohol?

No amount of alcohol is entirely safe to drink while on Zoloft®. This medication affects mood and behavior, and alcohol is a central nervous system depressant. When combined, the effects of Zoloft® and alcohol can be unpredictable and potentially dangerous. If you’re taking Zoloft® and considering drinking alcoholic beverages, you must talk to your healthcare provider first.

Interactions Between Alcohol and Zoloft®

Alcohol is considered a drug just like Zoloft®, and like all drugs, taking more than one at a time can significantly put your health at risk. There are harmful interactions apart from significant depression that the mixture can cause in your body, including:

  • Altered communication pathways and functions in the brain
  • Changes to normal moods, behaviors, and feelings
  • Damaged motor coordination, movement skills, and memory loss
  • Difficulty thinking, controlling impulses, and decision making
  • Increased memory impairment, impulsivity, violence

In addition, since alcohol is a central nervous system (CNS) depressant, drinking—especially heavily—can worsen depressive symptoms.

If you drink alcohol while taking sertraline (Zoloft®), you are at higher risk of experiencing the following:

  • serotonin syndrome
  • new or worse suicidal thoughts and behavior
  • excessive sedation
  • toxicity

Zoloft® and Alcohol Contraindications

There are certain situations in which it’s especially important to avoid drinking alcohol while taking Zoloft®, such as:

  • If you have a history of alcohol abuse or addiction
  • If you’re taking high doses of Zoloft®
  • If you’re pregnant or breastfeeding

In these situations, it’s important to talk to your healthcare provider about the potential risks and benefits of combining Zoloft® and alcohol. They can help you determine the best action and provide personalized recommendations to keep you safe.

Zoloft® and Other Drugs

Aside from alcohol, other drugs can interact with Zoloft® and may have serious health consequences. The following drugs are known to interact with Zoloft®:

  • Monoamine oxidase inhibitors (MAOIs)
  • Blood thinners like Warfarin (Coumadin) or Aspirin
  • Medications that affect heart rhythms, like Pimozide or Digitoxin
  • Serotoninergic drugs or drugs that increase serotonin levels, including other types of SSRIs
  • Medications that are broken down by certain liver enzymes, such as Propafenone, Risperidone, Flecainide, Tolterodine, Metoprolol, Atomoxetine, and Venlafaxine

Please note that the above does not show the complete list of medications that interact with Zoloft®. Let your healthcare provider know if you’re taking any medications, including over-the-counter medications and supplements. This will help them determine whether it’s safe to combine these medications with Zoloft®.

Zoloft® and Caffeine Interaction

Caffeine is a stimulant shown to alter mood and behavior, enhancing focus and decreasing drowsiness. The combination of caffeine and Zoloft®, both substances that affect mood, can have unexpected consequences.

One of the main ways caffeine and Zoloft® can affect each other is by increasing the risk of side effects. For example, caffeine can make you more likely to feel jittery, anxious, and restless, while Zoloft® can make you sleepy and tired. When all of these side effects happen at once, it can be uncomfortable and even dangerous.

Also, caffeine can make you more likely to have heart palpitations and other heart problems. This can be especially scary for people who have had heart disease or other health problems.

It’s important to know that how caffeine and Zoloft® interact can be different for each person. This depends on how much Zoloft® a person takes, how much caffeine they drink, and their overall health and medical history.

Zoloft®, Alcohol, and Suicide

Zoloft® is used to treat depression, anxiety, and other mental health issues. However, combined with alcohol, it becomes extremely harmful and can raise the risk of suicidal thoughts and actions.

Since alcohol is a CNS depressant, it might amplify the drowsiness caused by Zoloft® and other antidepressants. You are also at higher risk of oversedation, toxicity, and suicidal thoughts or behaviors. Combining the two can potentially reduce the medication’s ability to improve mental wellness.

If you are taking Zoloft® or any other antidepressant, you should not drink alcohol or limit your consumption. This is especially important for people who have tried to commit suicide or had suicidal thoughts in the past because combining alcohol and Zoloft® can make the risk of suicide even higher.

If you’re struggling with suicidal thoughts or behaviors, seeking help as soon as possible is essential. This can include talking to a trusted friend or family member, reaching out to a mental health professional, or calling suicide hotlines. The National Suicide Prevention Lifeline can be reached at 1-800-273-TALK and is only one of many available options. Remember, help is always available, and you don’t have to struggle alone. Reaching out for help can be a brave and positive step toward healing and recovery.

Treatment Options for Alcohol Use and Major Depressive Disorder

Alcohol use disorder (AUD) is a serious and complex condition affecting millions globally. It’s characterized by excessive alcohol consumption that interferes with daily life and causes significant distress.

If left untreated, alcohol abuse can lead to many negative consequences, including physical health problems, social and financial difficulties, and relationship problems.

Fortunately, various treatment options are available for individuals struggling with AUD. These include:

  • Behavioral therapies. Cognitive-behavioral therapy (CBT), motivational interviewing (MI), and contingency management (CM) are effective behavioral therapies that can help individuals overcome AUD.
  • Medications. Certain medications, such as naltrexone, acamprosate, and disulfiram, can be effective in reducing alcohol cravings and preventing relapse.
  • Support groups. Joining a support group like Alcoholics Anonymous (AA) or others can provide individuals with emotional support and practical advice on overcoming AUD.
  • Inpatient treatment. Inpatient treatment programs offer a comprehensive and intensive approach to treating AUD and alcohol dependence. These programs typically involve a combination of behavioral therapies, medications, and support groups.
  • Outpatient treatment. Outpatient treatment programs are designed for individuals who need help overcoming substance abuse but cannot participate in an inpatient treatment program.
  • Substance abuse counseling. Counseling and therapy, both in groups and one-on-one, can help you figure out why you have a problem with alcohol and help you get over the psychological aspects of your alcohol dependence. You might benefit from couples or family therapy. Having the support of your family can be a crucial factor in the process of recovery and improvement.

Please note that the most effective treatment for alcohol use disorder will depend on the individual’s unique circumstances, including their drinking history, medical history, and personal preferences.

Find Alcohol Abuse Rehab Centers Near You

If you or someone you love is struggling with alcohol addiction, seeking professional help is an important step toward recovery. Addiction treatment centers specialize in helping individuals overcome alcohol addiction and provide a supportive and safe environment for individuals to begin their journey toward sobriety.

Design for Recovery provides long-term sobriety through one-on-one mentorship, weekly house gatherings, employment support, money management, family outreach, and a firm foundation based on the 12 Steps of Alcoholics Anonymous.

Its two houses, located near the beach in Mar Vista and Playa del Rey, West Los Angeles, give a comfortable foundation to thrive in a safe and active environment with plenty of recreational activities, community assistance, and jobs.

Reach out to us today to find out more.

Frequently Asked Questions

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Drinking alcohol while taking Zoloft® can interfere with the effectiveness of the medication. It can also increase the risk of side effects such as drowsiness, dizziness, and impaired judgment. In some cases, it may also increase the risk of serotonin syndrome, a potentially life-threatening condition. If you choose to drink, it is important to do so in moderation and seek professional medical advice about the potential risks.

Alcohol might worsen Zoloft®’s side effects, such as drowsiness, dizziness, and concentration issues. Since alcohol is a central nervous system depressant, light or heavy drinking can also worsen symptoms of depression.

Alcohol can temporarily increase serotonin and dopamine levels, which help regulate your mood. You may feel better when you consume alcohol, but this feeling won’t last. Alcoholic beverages can make your depression worse because it’s a neurological suppressant that works to inhibit the neurological signals in your brain.

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

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Harmer, C. J., & Cowen, P. J. (2013). ‘it’s the way that you look at it’—a cognitive neuropsychological account of SSRI action in depression. Philosophical Transactions of the Royal Society B: Biological Sciences, 368(1615), 20120407.

Moncrieff, J., Cooper, R. E., Stockmann, T., Amendola, S., Hengartner, M. P., & Horowitz, M. A. (2022). The serotonin theory of depression: A Systematic Umbrella Review of the evidence. Molecular Psychiatry.

Sarko, J. (2000). Antidepressants, old and new. Emergency Medicine Clinics of North America, 18(4), 637–654.

Sertraline (Zoloft). NAMI. (n.d.). Retrieved February 8, 2023, from,adolescents%20aged%206%2D17%20years.

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Viatris Inc. . (n.d.). Home. Depression Treatment | ZOLOFT® (sertraline HCl) | Safety Info. Retrieved February 8, 2023, from

Witkiewitz, K., Litten, R. Z., & Leggio, L. (2019). Advances in the science and treatment of alcohol use disorder. Science Advances, 5(9).

Clinically Reviewed by Linda Whiteside, LPCC

Medically Reviewed by: Dr. Ryan Peterson, MD

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Written By: Linda Whiteside

Licensed Clinical Professional Counselor who has been providing mental health services for over 10 years.

Medically reviewed by: Dr. Ryan Peterson

Went to medical school at The George Washington University School of Medicine in Washington, D.C.

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