How Long Does Trazodone Stay In Your System?

Disclaimer: This article is for educational purposes only and does not replace expert medical or mental health advice. Trazodone use and dosage for depression or other mental health conditions require a comprehensive evaluation by a qualified clinician. So, always refer to a licensed mental health specialist for specific direction or treatment.

Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). It can be prescribed by your doctor for major depressive disorder, anxiety disorders, and sleep troubles. Trazodone balances the serotonin levels in your brain. If you have been prescribed trazodone, you might want to know how long trazodone lasts in your system. While this can vary depending on the dosage and your metabolism rate, it typically takes 1 to 3 days for it to be eliminated from your system.

Trazodone’s half-life can range between 3 and 9 hours. This means it takes this time to eliminate 50% of the trazodone from your system, then the 50% of the remaining half, and so on.

Typically, it takes a few half-lives to eliminate trazodone from your system entirely. This also varies from person to person - depending on the dosage, metabolism rates, and other factors.

Trazodone gets eliminated from your body within 3 days of the last dose. However, depending on the type of test conducted, trazodone can remain detectable in your system for varying periods of time.

How Long Does Trazodone Stay in Your Urine?

Trazodone remains detectable in your urine for up to 2-4 days after the last dose. However, certain metabolites can show up even up to 26 days after the last dose.

How Long Does Trazodone Stay in Your Saliva?

Trazodone can show up in the saliva as soon as 4 hours and up to 4 days after the last dose. Saliva testing, though conducted less frequently than urine or blood tests, is relatively non-invasive for finding recent trazodone use.

How Long Does Trazodone Stay in Your Blood?

Trazodone may remain detectable in your blood up to 3 days after the last dose. However, as blood tests are slightly more invasive than others, they are not typically used except in clinical settings.

How Long Does Trazodone Stay in Your Hair?

Hair testing has the longest detection window for Trazodone use. It can be detected in the hair for up to 90 days. Hair testing is not typically used except when there is a need to establish a more extended history of drug use.

Certain factors can impact how long does trazodone stay in your system:

• Dosage and Frequency: Higher and more frequent doses of trazodone can slow down the elimination rate. This is why the medication must be taken only as prescribed by your doctor.
• Metabolism: Quicker metabolism rates lead to quicker elimination rates. Maintaining an active lifestyle and keeping your body hydrated are crucial for faster metabolism.
• Age: Aging can slow down metabolism, so it may take longer to eliminate the medicine from the system as one ages.
• Liver and Kidney Functioning: Optimal liver and kidney functioning play a crucial role in effectively eliminating trazodone from the body. Pre-existing liver or kidney conditions can slow down the elimination rates.
• Body Weight and Composition: The higher the body weight, the longer it takes for trazodone to be eliminated from the body.

Sometimes, trazodone can lead to false positives for amphetamines, and rarely ecstasy and LSD.

When this SARI is metabolized in your body, one of the byproducts is m-CPP. When clinical trials published in the National Library of Medicine (NLM) tested for urine samples containing no amphetamine, methamphetamine, or ecstasy, it was found that sufficient levels of m-CPP can lead to false positives for amphetamines.

Trazodone has not been found to be addictive, but it is prescribed for longer periods of time - so it can lead to dependence. If you are struggling with depressive symptoms or trazodone use - reach out to the NuView Treatment Center today!

We offer personalized and structured care options, such as partial hospitalization programs and intensive outpatient programs, so that you can heal in safe and non-judgmental settings at your own pace.

Why is trazodone prescribed?

Trazodone is a serotonin antagonist and reuptake inhibitor that is prescribed for major depressive disorder, anxiety disorders, and sleep disturbances.

How long does it take for trazodone to show effect?

It typically takes 1-2 weeks for trazodone to show effect, for you to feel an improvement in your depressive, anxiety, or sleep symptoms. However, these outcomes can vary from person to person.

What are the types of trazodone testing?

• Urine Test: It detects the medicine up to 2-4 days after the last dose; some metabolites can be detected up to 26 days.
• Saliva Test: It detects the medicine for up to 4 days after the last dose.
• Blood Test: It detects the medicine for up to 3 days after the last dose.
• Hair Test: It detects the medicine for up to 90 days.

Is trazodone addictive?

There is no evidence to show that trazodone is addictive; however, longer use can lead to dependence. This is why slow tapers can be recommended sometimes.

What if trazodone leads to a false positive?

Trazodone can sometimes lead to a false positive for amphetamine, ecstasy, or LSD. This is why confirmatory tests that are more specific, gas chromatography-mass spectrometry, are crucial.