How Long Does Trazodone Stay In Your System?

Reviewed by: Dr. Ryan Peterson
Updated on: May 6, 2025

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What is Trazodone?

Trazodone is a serotonin antagonist and reuptake inhibitor (SARIs). It is widely used in the treatment of major depressive disorder. It can be used to treat anxiety and sleep troubles as well.

Trazodone mainly works by balancing the serotonin levels in your brain. It stays in your system and can be found in your liver, blood, and urine. While how long Trazodone lasts in your system can vary depending on the dosage, metabolism rates, and other personal factors, typically, it takes 1 to 3 days for your body to eliminate it completely.

Trazodone Half-Life

Trazodone is considered to have a half-life of 5 to 13 hours. This means that Trazodone levels will drop by 50% in your blood every 5-13 hours. It needs an average of 5.5 half-lives to get eliminated from the system entirely. However, this also depends on factors like dosage, metabolism, age, weight, and overall health.

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What Factors Affect How Long Does Trazodone Last In Your System?

Trazodone can get cleared from your system in 1 to 3 days. However, here are some factors that play a major role in effectively clearing Trazodone from your system:

Metabolism: Metabolism is central to Trazodone elimination. Efficient metabolism rates play a role in quickly clearing Trazodone from your system. Therefore, maintaining an active lifestyle and keeping your body hydrated is crucial.

Dosage and Frequency: Higher and more frequent doses of Trazodone can lower the elimination rate. Therefore, only take Trazodone as is prescribed by your doctor.

Age: Age affects the Trazodone elimination rate via metabolism, as with age, metabolism rates also slow down. So, it may take longer to eliminate the medicine from the system as one ages.

Liver and Kidney Functioning: Optimal liver and kidney functioning play a crucial role in effectively eliminating Trazodone from the body. Pre-existing medical conditions affecting liver and kidney functioning can directly affect the elimination rates.

Body Weight and Composition: The higher the body weight, the longer it takes for Trazodone to get eliminated from the body.

How Long Does Trazodone Last In Your System?

While Trazodone gets eliminated from your body within 3 days of the last dose, depending on the type of test, Trazodone can remain detectable in your system for varying periods of time.

How Long Does Trazodone Stay in Your Urine?

Trazodone remains detectable in your urine for up to 2-4 days after the last dose. However, certain metabolites can show up even up to 26 days after the last dose.

How Long Does Trazodone Stay in Your Hair?

Hair testing has one of the longest detection windows with regard to Trazodone use. Similar to many other medicines, Trazodone can be detected in the hair for up to 90 days and sometimes even longer from its use. Hair testing is not typically used except when there is a need to establish a more extended history of drug use.

How Long Does Trazodone Stay in Your Saliva?

Saliva tests are very sensitive and quick-acting. In saliva, Trazodone can show up as soon as 4 hours and may show up for up to 2 days after the last dose. Saliva testing, though conducted less frequently than urine or blood tests, is relatively non-invasive for finding recent Trazodone use.

How Long Does Trazodone Stay in Your Blood?

Trazodone may remain detectable in your blood up to 1-2 days after the last dose.

Given that it is slightly more invasive than the other tests and has a narrow window of detection, blood tests are not typically used unless there is urgency concerning the need to detect Trazodone.

Test Type

Detection Window

Urine

Up to 4 days

Hair

Up to 90 days

Saliva

Up to 2 days

Blood

Up to 2 days

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How can NuView help you?

At NuView, we believe that informed decision-making is central to your health and well-being. Therefore, how long Trazodone stays in your system is crucial in understanding its benefits and risks and getting the personalized information and care you need. If you have any questions or other concerns regarding Trazodone use, do not hesitate to reach out to us.

Have questions about Trazodone? Reach out to NuView for expert guidance now. Call (323) 307-7997 or email us at info@nuviewtreatment.com.

Frequently Asked Questions (FAQs)

How long does it take for your body to eliminate Trazodone?

Typically, it takes 1-3 days for your body to eliminate Trazodone.

How long does it take for Trazodone to take effect?

Trazodone takes effect in about 30 minutes to 2 hours after administration, depending on whether it is administered before or after food intake. It is most effective taken near bedtime with a light meal or snack.

What are the peak levels of Trazodone?

Trazodone gets quickly absorbed into your blood, and peak levels occur within 1-2 hours of consumption. During this time, the medicine is at its most effective.

What are the types of Trazodone testing?

Different tests detect Trazodone for varying periods of time:

  • Urine Test: It detects the medicine up to 2-4 days after the last dose; some metabolites can be detected up to 26 days.
  • Hair Test: It detects the medicine for up to 90 days.
  • Saliva Test: It detects the medicine for up to 2 days after the last dose.
  • Blood Test: It detects the medicine for up to 2 days after the last dose.

  • What is Trazodone?
  • Trazodone Half-Life
  • What Factors Affect How Long Does Trazodone Last In Your System?
  • How Long Does Trazodone Last In Your System?
  • How can NuView help you?
  • Frequently Asked Questions (FAQs)

  • What is Trazodone?
  • Trazodone Half-Life
  • What Factors Affect How Long Does Trazodone Last In Your System?
  • How Long Does Trazodone Last In Your System?
  • How can NuView help you?
  • Frequently Asked Questions (FAQs)

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