Medication for Benzo Withdrawal

Clinically Reviewed by Linda Whiteside, LPCC

Medically Reviewed by: Dr. Ryan Peterson, MD

Medication for Benzo Withdrawal: Manage Symptoms & Promote Recovery

Table of Contents

Benzodiazepines, or benzos, are medications often used to treat anxiety, panic disorders, and insomnia. They work by slowing down your central nervous system activity, helping you feel more relaxed or sleepy. However, if these medications are used for a long time or in high doses, dependence can develop. Dependence means your body has gotten used to the drug, and stopping or reducing use can lead to withdrawal symptoms.

Benzodiazepine withdrawal can be uncomfortable and even dangerous if not managed properly. Symptoms can include anxiety, restlessness, and trouble sleeping. In severe cases, withdrawal can cause seizures or psychosis, which affects the mind and can cause hallucinations or delusions.

While withdrawal can be challenging, medications can help manage the symptoms and make the process safer. These medications can ease symptoms, reduce cravings, and help prevent severe complications. By helping control withdrawal symptoms, medications also make it more likely that a person will stay in treatment and recover.

Medication-assisted treatment (MAT) combines medication with counseling and behavioral therapies. This approach is the gold standard for managing withdrawal from substances like benzos. The goal of MAT is not just to manage withdrawal symptoms but to help people recover from substance abuse and regain a healthy, productive life.

Benzo Withdrawal Syndrome: Symptoms and Challenges

Benzo Withdrawal Syndrome_ Symptoms and Challenges

Symptoms and Stages of Benzo Withdrawal

The symptoms of benzodiazepine withdrawal can range from mild to severe, often dependent on the specific benzodiazepine used, duration of use, dosage, and individual biological factors. Typically, these symptoms are divided into psychological and physical categories.

Psychological symptoms might include:

  • Anxiety: Heightened feelings of nervousness, restlessness, and worry are common in benzodiazepine withdrawal. This is partly due to the central nervous system becoming overstimulated following benzodiazepine discontinuation.

  • Depression: It’s common to experience sadness, hopelessness, and lack of interest in previously enjoyable activities. These symptoms might be particularly pronounced in individuals with a pre-existing mental health disorder.

  • Irritability: Benzodiazepine withdrawal can cause mood instability, often manifesting as irritability and agitation.

  • Insomnia: Sleep disturbances, including difficulty falling asleep, staying asleep, or experiencing restful sleep, are common withdrawal phenomena.

  • Panic Attacks: Acute bouts of intense fear or discomfort, characterized by symptoms such as rapid heartbeat, sweating, trembling, and a sense of impending doom, can occur during benzodiazepine withdrawal, particularly in individuals with a history of panic disorder.

  • Cognitive Impairment: This may include difficulty with memory, concentration, and decision-making processes.

Physical symptoms might include:

  1. Tremors: Involuntary, rhythmic muscle movements, typically affecting the hands, are common in benzodiazepine withdrawal.

  2. Seizures: This is a severe and potentially life-threatening withdrawal symptom, particularly relevant to those on higher doses or those who abruptly discontinue benzodiazepine use.

  3. Gastrointestinal Problems: Nausea, vomiting, and diarrhea can occur during the withdrawal process.

  4. Muscle Pain: Some individuals might experience muscle aches and pains.

  5. Headache: Headaches, ranging from dull to severe, are a common symptom of benzodiazepine withdrawal.

  6. Heart Palpitations: The feeling of having a rapid, fluttering, or pounding heart can be a physical manifestation of anxiety or the body’s response to benzodiazepine discontinuation.

Stages of Benzo Withdrawal

The benzodiazepine withdrawal timeline can generally be categorized into two stages, namely acute withdrawal and protracted withdrawal, although the exact timing and symptom severity can vary among individuals.

  1. Acute Withdrawal: This phase usually begins within a few hours to a few days after discontinuing benzodiazepine use and can last up to several weeks. Both physical and psychological symptoms, including anxiety, restlessness, insomnia, and physical symptoms like heart palpitations and gastrointestinal issues characterize acute withdrawal.

  2. Protracted Withdrawal: Also known as the prolonged benzodiazepine withdrawal syndrome, this stage can last for several months or even years following discontinuation. Symptoms during this stage might include chronic anxiety, depression, and cognitive impairments. Some individuals might also experience ongoing physical symptoms, although these are typically less severe than those seen during the acute withdrawal phase.

The goal of any benzodiazepine withdrawal treatment should be to minimize discomfort and ensure patient safety. In addition to pharmacological interventions, psychological support from mental health professionals and support groups can be beneficial during the withdrawal process. Further, strategies like gradual dose reduction can help mitigate withdrawal severity. With proper management, individuals can successfully navigate the process of benzodiazepine withdrawal and move toward recovery.

Assessing the Severity and Risks Associated with Benzo Withdrawal

The severity of benzo withdrawal can vary depending on several factors. These can include the type of Benzo you’ve been using, how long you’ve been using it, and the dose. People who have been using benzos for a long time or in high doses may experience more severe withdrawal symptoms.

Benzodiazepine withdrawal can also carry risks. Severe symptoms, such as seizures, can be life-threatening. Additionally, the distress from withdrawal symptoms can increase the risk of self-harm or suicide. Therefore, it’s crucial to seek medical help if you’re trying to stop benzos.

Recognizing the Importance of Medical Intervention in Benzo Withdrawal

Given the potential severity and risks of benzodiazepine withdrawal, medical intervention is often necessary. Medical professionals can help manage symptoms and ensure safety during the withdrawal process. Treatment often involves the use of medications, along with counseling and support.

Medications Used to Treat Benzo Withdrawal Symptoms

Benzodiazepine Tapering: Gradual Reduction for Safe Withdrawal

The first step towards managing benzodiazepine withdrawal is implementing a careful, gradual reduction of the drug, known as tapering. This is crucial because abrupt discontinuation of these substances can precipitate severe withdrawal syndrome. When it comes to benzodiazepine mono-dependence management, the following steps are usually taken:

  1. Assess the Type of Benzodiazepine: The process will differ based on whether the patient is using a long-acting benzodiazepine like diazepam, an intermediate-acting benzodiazepine like lorazepam, or a short-acting benzodiazepine like alprazolam. Long-acting benzodiazepines may require a more prolonged tapering process compared to shorter-acting benzos.

  2. Establish Dosage: The current dose of the benzodiazepine will influence the tapering plan. Higher doses typically require a slower and more cautious reduction schedule.

  3. Adjust According to Response: Regular assessments of withdrawal severity will determine the rate at which the dose is reduced. If symptoms persisting are severe, the tapering process may need to be slowed down.

Antidepressants: Easing Anxiety and Mood Symptoms

Benzodiazepines are often prescribed to treat anxiety and panic disorders. Hence, during withdrawal, these symptoms can re-emerge or even intensify, a phenomenon known as rebound anxiety. Antidepressants may be used as part of the benzodiazepine discontinuation plan to manage these symptoms. Here are some common options:

  • Selective Serotonin Reuptake Inhibitors (SSRIs): SSRIs like fluoxetine (Prozac) and sertraline (Zoloft) increase the level of serotonin, a neurotransmitter involved in mood regulation. These can be beneficial in managing anxiety and depressive symptoms during withdrawal.

  • Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs): Venlafaxine (Effexor) is an example of an SNRI. SNRIs work similarly to SSRIs but also increase norepinephrine levels, offering an additional avenue for mood stabilization.

Anticonvulsants: Preventing Seizures and Managing Other Symptoms

Benzodiazepines act on the central nervous system (CNS), reducing activity and providing relief from conditions like anxiety, insomnia, and muscle spasms. During withdrawal, a rebound effect can occur where the CNS becomes overactive, increasing the risk of seizures. Here are some anticonvulsants used:

  • Gabapentin (Neurontin): Gabapentin is often used in benzodiazepine-dependent populations to help manage withdrawal symptoms. This drug’s basic pharmacologic mechanisms involved in stabilizing nerve activity make it effective in preventing seizures and managing symptoms like sleep disturbance and anxiety.

  • Pregabalin (Lyrica): Similar to gabapentin, pregabalin is used to manage benzodiazepine withdrawal symptoms and prevent the risk of seizure disorders associated with the withdrawal process.

Beta Blockers: Reducing Physical Symptoms

As benzodiazepine withdrawal can trigger an increased stress response, physical symptoms such as elevated heart rate and blood pressure can occur. Beta blockers, which reduce the effects of adrenaline, can help manage these symptoms. Here are some examples:

  • Propranolol (Inderal): Used to manage physical symptoms of withdrawal such as increased heart rate and tremors, this medication helps in controlling the body’s response to the stress of withdrawing benzodiazepines.

  • Atenolol (Tenormin): This is another commonly used beta blocker that can reduce the physical symptoms associated with benzodiazepine withdrawal, aiding in the reduction of panic attacks and blood pressure spikes that may be experienced during the withdrawal period.

Understanding the Mechanism of Action of These Medications

Understanding the Mechanism of Action of These Medications

Benzodiazepine Tapering: Managing the Brain’s Adjustment

Benzodiazepine tapering is a critical step in overcoming benzodiazepine dependence. The process of tapering is essentially a method of gradual dose reduction intended to help the brain and central nervous system adjust to the absence of the drug. After long-term use, the brain becomes accustomed to the presence of benzodiazepines and their effect on the neurotransmitter gamma-aminobutyric acid (GABA). When the drug is suddenly discontinued, it can cause an imbalance, leading to withdrawal symptoms. The process of tapering involves:

  1. Gradually lowering the dose: This can be done by reducing the frequency or amount of the prescribed benzodiazepines, aiming to minimize the severity of withdrawal reactions.

  2. Monitoring withdrawal symptoms: Healthcare providers will typically monitor patients closely during this process to manage potential withdrawal syndrome and adjust the tapering plan as necessary.

  3. Providing support and additional treatment: This can include therapy, support groups, or other methods of psychosocial intervention to aid the process of benzodiazepine discontinuation.

Antidepressants: Regulating Neurotransmitters

Antidepressants play a key role in the management of mood and anxiety symptoms, often experienced during benzodiazepine withdrawal. They work by regulating neurotransmitters, which are chemicals that transmit signals in the brain. The functions of antidepressants encompass:

  1. Enhancing neurotransmitter levels: Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) increase the levels of serotonin and norepinephrine in the brain, promoting mood stabilization and reducing anxiety.

  2. Prolonging neurotransmitter activity: By preventing the reabsorption of these chemicals into the nerve cells, antidepressants extend their activity and help maintain balanced mood states.

  3. Assisting in long-term recovery: Ongoing use of antidepressants can be a part of the long-term strategy for managing protracted withdrawal symptoms and the mental health aspects of recovery.

Anticonvulsants: Stabilizing Nerve Activity

Anticonvulsants are another important class of medications used in benzodiazepine withdrawal management. They are particularly effective in preventing seizures, a severe withdrawal symptom that can occur in some individuals. These drugs exert their effects by:

  • Modifying the action of neurotransmitters and ion channels, anticonvulsants reduce neuronal overactivity, a phenomenon that can occur during benzo detox.

  • Alleviating a variety of symptoms associated with benzodiazepine withdrawal, thereby facilitating the withdrawal process.

  • Minimizing the risk of severe withdrawal syndrome for individuals on higher doses of benzodiazepines or those withdrawing abruptly. Anticonvulsants can lower the risk of potentially life-threatening seizures.

Beta Blockers: Managing the Body’s Stress Response

Beta blockers serve to manage the physical symptoms of benzodiazepine withdrawal, such as a rapid heart rate, high blood pressure, and tremors. They operate by:

  • Blocking the effects of adrenaline: Also known as the body’s “fight or flight” hormone, adrenaline can cause increases in heart rate, blood pressure, and other physical stress responses. By blocking the action of adrenaline, beta blockers can reduce these symptoms.

  • Stabilizing physical symptoms: The use of beta blockers helps to manage the body’s physiological responses to benzodiazepine withdrawal, providing comfort and minimizing distress.

  • Facilitating recovery: By reducing physical stress responses, beta blockers can help

Evaluating the Efficacy and Safety of Medications for Benzo Withdrawal

Evaluating the Efficacy and Safety of Medications for Benzo Withdrawal

Efficacy: Success Rates and Improvement in Quality of Life

Medication-assisted treatment (MAT) is considered a robust approach to managing benzodiazepine withdrawal. It has demonstrated considerable success rates and notable improvements in patients’ quality of life. The efficacy of such treatments can be measured by:

  • Reduction in withdrawal symptoms: Studies indicate that tapering, as a part of MAT, significantly reduces withdrawal symptoms, including both acute withdrawal and protracted withdrawal syndrome.

  • Improvement in treatment outcomes: The use of medications like antidepressants, anticonvulsants, and beta blockers in conjunction with other treatments has been linked to better outcomes, including a decrease in benzodiazepine use and dependence.

  • Quality of life enhancements: Effective management of withdrawal symptoms and overcoming withdrawal challenges can lead to an improved overall quality of life, including better mental health and decreased substance abuse.

Combination with comprehensive treatment: Medications tend to be most effective when integrated into a comprehensive treatment plan, which often includes prescribed benzodiazepines for gradual withdrawal, psychoactive substance management, psycho-social interventions, and support for mental disorders.

Safety: Risks and Side Effects of Medications

Despite their benefits, medications used in benzodiazepine withdrawal treatment are not without risks and side effects. It’s crucial to consider the safety profile of these drugs:

  • Antidepressants: While beneficial in managing mental health disorders and anxiety disorders related to withdrawal, these drugs may cause nausea, insomnia, and changes in appetite.

  • Anticonvulsants: Useful in preventing severe withdrawal syndrome like seizures, anticonvulsants can lead to dizziness, fatigue, and weight changes.

  • Beta Blockers: Effective in managing physical symptoms, beta blockers may cause tiredness, cold hands or feet, and a slow heartbeat.

  • Risk of Dependence: Some medications used in the treatment, especially other benzodiazepines used for tapering, carry a risk of dependence and withdrawal phenomena, necessitating careful medical supervision during benzodiazepine discontinuation.

Importance of Individualized Treatment Plans

Given the potential side effects and risks associated with these medications, the importance of an individualized treatment plan is paramount. Successful withdrawal and recovery often involve:

  • Personalized symptom management: Treatment plans should be tailored to the person’s specific withdrawal symptoms, mental health status, and overall health.

  • Evaluation of personal circumstances: Factors like the patient’s environment, personal history of substance abuse, and the presence of co-occurring mental disorders play a crucial role in shaping the treatment approach.

  • Professional medical supervision: Supervised medical detox, involving close monitoring by healthcare providers, helps ensure the safe and effective use of medications.

  • Balancing benefits and risks: A careful assessment of the benefits of medications against their potential side effects is critical in devising an individualized treatment plan. This includes considering factors such as benzodiazepine tolerance, the potential for benzodiazepine harmful use, and the timeline of withdrawal.

Incorporating Behavioral Therapies in Medication-Assisted Treatment

Incorporating Behavioral Therapies in Medication-Assisted Treatment

Cognitive Behavioral Therapy (CBT): CBT can be particularly effective in helping people manage the psychological symptoms of benzo withdrawal. CBT helps people understand and change thought patterns that lead to harmful behaviors or emotions and can be useful in managing increased anxiety during withdrawal.

Contingency Management (CM): CM involves giving tangible rewards to reinforce positive behaviors, such as staying drug-free. This type of therapy can increase motivation and make it more likely that a person will stay in treatment.

Motivational Interviewing (MI): MI is a counseling method that helps people resolve their ambivalence about change and make positive decisions about their treatment. This can be particularly useful in the early stages of withdrawal, when motivation to continue may be low.

Family Therapy: Family therapy involves treating the family as a unit and can help improve communication and reduce conflict. This type of therapy can provide support during the withdrawal process and help prevent relapse.


Withdrawal from benzodiazepines can be challenging, but with the right support and treatment, recovery is achievable. Medications can play a key role in managing withdrawal symptoms and promoting recovery. When combined with therapy and support, they can help individuals regain control of their lives and achieve lasting recovery.

It’s essential to remember that everyone’s journey to recovery is different, and what works for one person may not work for another. The most effective treatment plans are personalized to meet an individual’s unique needs and circumstances.

Above all, it’s crucial to seek help if you’re struggling with benzodiazepine dependence. With the right treatment and support, you can overcome withdrawal and move forward toward a healthier, drug-free life.

Take Control of Your Journey: Get Expert Help at NuView Treatment Center Today

Take Control of Your Journey : Get Expert Help at NuView Treatment Center Today

Struggling with benzodiazepine withdrawal can feel overwhelming and sometimes hopeless. But remember, you are not alone. There’s a team of professionals ready to provide the care and support you need. NuView Treatment Center offers comprehensive, personalized treatment plans to manage benzodiazepine withdrawal and guide you toward recovery.

At NuView, we understand that everyone’s journey is unique. That’s why our approach to treatment is as individual as you are. From carefully monitored medical detox to mental health support and counseling, we focus on your holistic well-being. We consider all aspects of your health and life, offering a mix of therapy, medication-assisted treatment, and supportive services to help you overcome withdrawal symptoms and regain control of your life.

Don’t let benzodiazepine dependence define your life. Reach out to NuView Treatment Center today. Start your journey towards a healthier, substance-free future. We’re here to help every step of the way.

Take the first step. Contact NuView Treatment Center now.

FAQs about Benzodiazepine Abuse, Withdrawal, and Treatment

Benzodiazepine abuse refers to the misuse or overuse of prescribed benzodiazepines or taking the drug without a prescription. This abuse can lead to dependence and withdrawal symptoms when the drug use is reduced or stopped.

Protracted withdrawal syndromes, also known as post-acute withdrawal symptoms (PAWS), are persistent symptoms that continue for weeks or even months after stopping benzodiazepines. These may include anxiety, insomnia, depression, and cognitive deficits.

A benzodiazepine receptor antagonist is a drug that blocks the effects of benzodiazepines on the central nervous system. An example is flumazenil, which is sometimes used in clinical settings to reverse the sedative effects of benzodiazepines.

Yes, withdrawal symptoms can be reduced through a process called tapering, which involves gradually reducing the dose of benzodiazepines under medical supervision. Other drugs and therapies may also be used to manage specific symptoms.

Some other drugs that can help manage benzodiazepine withdrawal symptoms include antidepressants, anticonvulsants, and beta blockers. Always consult with a healthcare provider before starting any new medication.

The difference lies in the half-life of the drugs. Short-acting benzodiazepines, such as Xanax, have a shorter half-life and are eliminated from the body more quickly. In contrast, long-acting benzodiazepines, like Valium, have a longer half-life and are eliminated more slowly.

Treatment typically involves a combination of medical detox, gradual withdrawal, medication-assisted treatment, and psychosocial interventions like cognitive-behavioral therapy (CBT) or support groups.

The withdrawal timeline can vary depending on the specific benzodiazepine used, how long it has been used, and the dosage. Acute withdrawal symptoms often begin within a few days to a week after discontinuation and can last for several weeks, while protracted withdrawal symptoms can last for months.

Benzodiazepine addiction can exacerbate existing mental health disorders like anxiety and depression. Additionally, withdrawal from benzodiazepines can cause severe anxiety, panic attacks, and other mental health symptoms.

Benzodiazepine Tapering Strategies and Solutions.” Benzodiazepine Information Coalition, 2023,

Pages, K P, and R K Ries. “Use of anticonvulsants in benzodiazepine withdrawal.” The American journal on addictions vol. 7,3 (1998): 198-204.

Tyrer, P et al. “Benzodiazepine withdrawal symptoms and propranolol.” Lancet (London, England) vol. 1,8219 (1981): 520-2. doi:10.1016/s0140-6736(81)92861-0

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Written By: Linda Whiteside

Licensed Clinical Professional Counselor who has been providing mental health services for over 10 years.

Medically reviewed by: Dr. Ryan Peterson

Went to medical school at The George Washington University School of Medicine in Washington, D.C.

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